Natural 20
A Natural 20 indicates a roll of 20 on a d20. A Natural 20 on an Attack roll is an automatic Hit (Full Hit in the case of Weapon Attacks), even if the target's defense is so high that the attack would miss normally (or would be a Glancing Hit). Additionally, if a Natural 20 is rolled on an Opposed Check, the roller of the Natural 20 automatically wins (unless both opponents roll a 20, then the contest goes to the higher result as normal).
A Natural 20 on an attack roll will also overcome a target's Damage Reduction and Damage Resistance (but not Damage Immunity), providing the result would hit normally. This includes Magic Resistance and Turn Resistance (but not Magic Immunity).
Alternatively, a Natural 1 always fails to attack or always loses an opposed check.